ABSTRACT
Infantile spasms (IS) is an age dependent epileptic encephalopathy in early infancy. Early diagnosis and treatment (within 4 weeks of onset) are beneficial to the termination of seizures and long-term cognitive protection. This paper reviewed the related literatures in the treatment of infantile spasms, mainly including the first-line and second-line drugs, the ketogenic diet and surgical treatment, to discuss the recent advances in the treatment of infantile spasms.
ABSTRACT
@#The enriched environment is an artificial environment for animal models of rodentia. In the enriched environment, model animals may improve synaptic plasticity, inhibit apoptisis and regulate autophage after hypoxic-ischemic brain damage, that promote the recovery.
ABSTRACT
Aim: To study new chemical constituents of the leaves of Ginkgo biloba L. Methods: Isolation and purification were carried out by several chromatographic methods. The structures of the compounds were elucidated by detailed analysis of their UV, IR, MS, ~1H NMR and ~(13)C NMR spectra Results: A new ginkgolide, ginkgolide N( 1, 7, 10-trihydroxy-3,14- dehydroginkgolide, Ⅱ), along with a known compound, was isolated from the leaves of G. biloba. The structure of the known one was elucidated as ginkgolide L(Ⅰ). Conclusion: Compound Ⅱ was a new compound. The complete spectroscopic data of compound Ⅰ were reported for the first time.
ABSTRACT
To investigate the chemical constituents from the aerial parts of Lygodium japonicum. Methods:Various chromatographic techniques were employed for isolation and purification of the constituents. The structures were elucidated by chemical evidence and spectral methods. Results:A new stigmasterol glycoside,(24R)-stigmastan-3β,5α,6β-triol 3-O-β-D-glucopyranoside (1),together with three known phenolic glycosides:6-O-p-coumaroyl-D-glucopyranose (2),6-O-caffeoyl-D-glucopyranose (3),1-O-(E)-caffeoyl-β-D-gentiobiose (4) were obtained and identified by spectroscopic methods. Conclusion:All compounds were isolated from Lygodiaceae for the first time.
ABSTRACT
Objective:To establish a determination of acteoside isomer in Total Cistanchis Glycosides Capsules by HPLC.Methods: HPLC analysis was carried out on C 18 ODS column with acetonitrile——1.5% acetic acid as the mobile phase. The linear gradient of acetonitrile was from 11.5% to 20%(0-25min). The detection wavelength was 335nm. Results: The method was linear in the range of 0.2～1.0?g, r =0.9996. The average recovery was 98.85%, RSD was 1.51%( n =9). Conclusion:This method is simple, accurate, highly sensitive and reproducible. It may be used for the determination of acteoside isomer in Total Cistanchis Glycosides Capsules.